Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml

Investigational new insulin glargine 300 U/ml has the same metabolism as insulin glargine 100 U/ml

Insulin glargine is processed in vivo into soluble 21(A) -Gly-human insulin (M1), the principal moiety responsible for metabolic effects, and subsequently into M2. This sub-study compared metabolism and metabolite pharmacokinetic (PK) profiles of investigational new insulin glargine U300 (Gla-300) with insulin glargine 100 U/ml (Gla-100, Lantus®, Sanofi-Aventis Deutschland GmbH, Frankfurt am Ma...

Abasria, INN-insulin glargine

Insulin glargine placental transfer Insulin Glargine Safety in Pregnancy: a Transplacental Transfer Study Short Title: Insulin glargine placental transfer

1 Division of Clinical Pharmacology and Toxicology, the Hospital for Sick Children, Toronto, Ontario, Canada, 2 Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada, 3 Division of Endocrinology, Mount Sinai Hospital, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, and 4 Department of Laboratory Medicine and Pathobiology, University of T...

An Evolutionary Perspective on Basal Insulin in Diabetes Treatment: Innovations in Insulin: Insulin Glargine U-300.

Rates of confirmed and severe, as well as nocturnal, hypoglycemia are generally lower with insulin glargine U-300 than insulin glargine U-100, thereby reducing an important concern of providers and patients regarding insulin therapy. Although a higher dose of insulin glargine U-300 than U-100 is required in most patients, the observed increase in body weight is small and less than with insulin ...

Insulin glargine: a long acting insulin analog.

The main goal of treatment of diabetes mellitus (DM) is to maintain long term near normoglycemia. Insulin therapy plays a pivotal role in the management of DM. Most insulin preparations and insulin delivery systems, do not mimic the physiological insulin secretion in the body, leading to impaired metabolic control and increased hypoglycemic attacks. Insulin glargine is newer, long acting insuli...